PermaLinkTMPermaLinkTM is a patented proprietary technology. The linker is designed to react efficiently with specific amino acids stably linking functional groups of your choice at defined locations on the protein surface. The chemical bond created by PermaLinkTM is stable to biological degradation in blood ensuring that the functional group remains attached. Two classes of PermaLinkTM reagents have been created with efficiency tailored for proteins and peptides.
- PermaLinkTM used novel chemisty to functionalise surface cysteine residues through a thio-ether bond, stable to biological and chemical degradation.
- Range of reagents customized for different sized proteins or peptides.
- Improved selectivity and control of PEGylation over maleimide methodology.
- High yields (>95%) for glycosylated/PEGylated peptides with the Glythera process.
